UNVEILING THE FUTURE OF BREAST CANCER THERAPY: CUTTING-EDGE ANTIBODY-DRUG CONJUGATE STRATEGIES AND CLINICAL OUTCOMES

Unveiling the future of breast cancer therapy: Cutting-edge antibody-drug conjugate strategies and clinical outcomes

Breast cancer has become the most prevalent malignant tumor worldwide and remains one of the leading causes of cancer-related mortality among women globally.The prognosis for patients with metastatic breast cancer remains poor, necessitating the exploration of novel therapeutic strategies to improve survival rates.In the era of precision medicine,

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Evaluation of the immunomodulatory activity of thalidomide on tumor-associated macrophages in the 4T1 murine metastatic breast cancer model

ABSTRACT The present work evaluated the immunomodulatory effect of thalidomide (Thal) at different doses on tumor-associated macrophages (TAMs) using a mouse model of human breast cancer.Mice were inoculated with 4T1 cells in the left flank Mop Handles and treated with Thal once a day at concentrations of 50, 100, and 150mg/kg body weight from the

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INTEGRATION OF QSAR AND SAR METHODS FOR THE MECHANISTIC INTERPRETATION OF PREDICTIVE MODELS FOR CARCINOGENICITY

The knowledge-based Toxtree expert system (SAR approach) was integrated with the statistically based counter propagation artificial neural network (CP ANN) model (QSAR approach) to contribute to a better mechanistic understanding of a carcinogenicity Rangehood Vent Hose model for non-congeneric chemicals using Dragon descriptors and carcinogenic po

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Governing Grazing and Mobility in the Samburu Lowlands, Kenya

Pastoral mobility is seen as the most effective strategy to make use of constantly shifting resources.However, mobile pastoralism as a highly-valued strategy to manage grazing areas and exploit resource variability is becoming more complex, due to recurrent droughts, loss of forage, government-led settlement schemes, and enclosure of land for commu

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